• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to secondary sidebar
  • Home
  • About
    • Contact
    • Privacy
    • Terms of use
  • Subscribe
  • Your Membership

Science and Technology News

Dedicated to the wonder of discovery

  • News
  • Features
  • Life
  • Health
  • Research
  • Engineering

A mathematical study describes how metastasis starts

January 30, 2021 by Editor

A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumor invades the epithelial cells and automatically quantifies the progression of the tumor and the remaining cell islands after its progression.

The model developed by these researchers could be used to better understand the biophysical characteristics of the cells involved when developing new treatments for wound healing, organ regeneration, or cancer progression.

This research analyses the collective movement of cells in tissues, a process that, in addition to being essential in pathological developments, such as tumor invasion and metastasis, plays a central role in physiological processes, such as wound healing, embryonic development or tissue reconstruction, for example.

In order to unravel the complexity of these processes, some previous scientific studies have carried out various experiments that seek to ascertain the role of certain chemical, mechanical and biological factors.

In this work, published in PLoS Computational Biology, researchers from the UC3M and UCM have now used a combination of mathematical modelling, numerical simulations and a topological analysis of data extracted from simulations and experiments in order to understand how cancer cells invade healthy cells.

“A simplification of the early stages of cancerous metastasis is that tumor cells move as a collective and displace a group of normal cells in healthy tissue,” explain the paper’s authors, Luis L. Bonilla and Carolina Trenado, from the UC3M Department of Mathematics, and Ana Carpio, from the UCM Department of Applied Mathematics.

“By selecting the right cell groups and using an appropriate software and cellular dynamics, we have been able to simulate the way in which cancerous cells invade healthy tissue,” the scientists note.

In order to carry out this simulation, they have used data from previous experiments and a Voronoi diagram (named after the Russian mathematician Gregory Voronoi) to conduct an irregular tessellation in which cells are polygons that do not overlap and have no spaces between them.

In the model, the centers of cells are subject to forces of a different origin, the researchers explain, some maintain tessellation and optimize the area and perimeter, others are inertial forces of biological origin, and there are active forces aligning the speeds of neighboring cells, as well as friction and noise.

In order to automatically track the progression of the barrier or boundary between cancerous and normal cells, researchers have used topological data analysis techniques, which are being used for the first time in this type of study.

“Based on a series of successive images from experiments, as well as numerical simulations, topological changes in the interfaces have been grouped, plotted, and classified automatically as the cancer cells progress,” note the scientists.

The techniques developed within the framework of this study can be scaled up to a larger volume of data, if these studies were to be carried out on a larger scale. In addition to this, these same techniques may be relevant in the field of tissue bioengineering to study how the biophysical characteristics of different materials affect organ and tissue regeneration.

Share this:

  • Twitter
  • Facebook
  • Print
  • LinkedIn
  • Reddit
  • Pinterest
  • WhatsApp

Filed Under: Life, News Tagged With: automatically, cancer, cancerous, carried, cells, data, experiments, forces, healthy, mathematical, metastasis, order, progression, researchers, simulations, study, techniques, tissue, topological, tumor, ucm

Primary Sidebar

Latest news

  • AutoX expands robotaxi operation zone to 1,000 sq km
  • Schaeffler acquires precision gearbox maker Melior Motion 
  • Sunflower Labs provides its security drone system to range of new customers
  • Monarch Tractor showcases ‘world’s first fully electric, driver-optional tractor’
  • Robot performs laparoscopic surgery without guiding hand of a human
  • Amazon owner’s Blue Origin to buy asteroid mining company Honeybee Robotics
  • Sydney scientists achieve ‘99 per cent accuracy’ for quantum computing in silicon
  • Ceremorphic unveils plans to build supercomputer infrastructure on 5 nanometer chips
  • Motion capture is guiding the next generation of extraterrestrial robots
  • Baidu’s autonomous electric carmaker Jidu raises $400 million in Series A financing

Most read

  • AutoX expands robotaxi operation zone to 1,000 sq km
    AutoX expands robotaxi operation zone to 1,000 sq km
  • Schaeffler acquires precision gearbox maker Melior Motion 
    Schaeffler acquires precision gearbox maker Melior Motion 
  • Sunflower Labs provides its security drone system to range of new customers
    Sunflower Labs provides its security drone system to range of new customers
  • Monarch Tractor showcases ‘world’s first fully electric, driver-optional tractor’
    Monarch Tractor showcases ‘world’s first fully electric, driver-optional tractor’
  • Robot performs laparoscopic surgery without guiding hand of a human
    Robot performs laparoscopic surgery without guiding hand of a human
  • Amazon owner’s Blue Origin to buy asteroid mining company Honeybee Robotics
    Amazon owner’s Blue Origin to buy asteroid mining company Honeybee Robotics
  • Sydney scientists achieve ‘99 per cent accuracy’ for quantum computing in silicon
    Sydney scientists achieve ‘99 per cent accuracy’ for quantum computing in silicon
  • Ceremorphic unveils plans to build supercomputer infrastructure on 5 nanometer chips
    Ceremorphic unveils plans to build supercomputer infrastructure on 5 nanometer chips
  • Motion capture is guiding the next generation of extraterrestrial robots
    Motion capture is guiding the next generation of extraterrestrial robots
  • Baidu’s autonomous electric carmaker Jidu raises $400 million in Series A financing
    Baidu’s autonomous electric carmaker Jidu raises $400 million in Series A financing

Live visitor count

209
Live visitors

Secondary Sidebar

Categories

  • Agriculture
  • Archaeology
  • Astronomy
  • Biology
  • Brain
  • Chemistry
  • Computer games
  • Computing
  • Digital Economy
  • Education
  • Energy
  • Engineering
  • Environment
  • Features
  • Genetics
  • Health
  • History
  • Industry
  • Life
  • Nature
  • News
  • Opinion
  • Physics
  • Research
  • Science
  • Social
  • Space
  • Technology
  • Uncategorized
  • Universe

Copyright © 2023 · News Pro on Genesis Framework · WordPress · Log in